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pentobarbital will reduce the level or result of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of abemaciclib with solid CYP3A4 inducers lowers plasma concentration of abemaciclib and its metabolites.pentobarbital will minimize the level or outcome of repaglinide by influencing